Special benefits Of Oxycodone

“The use of drugs containing oxycodone is reserved as a second-line treatment for severe pain of cancerous origin”, recalls the ANSM. With the improvement in pain management in France, the use of oxycodone-based specialties therefore increased between 2008 and 2013.

Collateral damage, oxycodone is more easily accessible and the risk of misuse increases tenfold. In addition to alleviating suffering, oxycodone – when chewed or crushed, then injected or inhaled – indeed produces the same sensations as heroin. This is why drug users often use it as a substitute. And the impact on the body is far from trivial. The risk of addiction is such that the World Health Organization (WHO) classifies this opioid among the most dangerous narcotics. That is to say level III of analgesics, a drug class that includes morphine and its derivatives intended for the treatment of intense pain.

Proven risks Of Oxycodone

Inadequate consumption of oxycodone multiplies the risk of digestive disorders, respiratory distress, hypotension and increases the frequency of episodes of confusion (loss of memory, difficulties in organizing oneself, finding one’s bearings in time and space ).

Finally, in the long term, the use of oxycodone disrupts hormonal functioning and weakens the immune system. The delivery of this molecule against a chronic non-cancerous disease must therefore “be assessed with precision so as not to use ineffective medication (…) which could cause deleterious effects, or even lead the patient to a state of physical and/or psychological dependence. “, warns the ANSM.

This new advance, after other work unveiled in recent months in this field of research, opens the way to a new method of producing many plant-derived drugs, much faster and potentially less expensive, according to these Stanford University scientists. in California. Their study appears in the American journal Science.

They describe how they managed to genetically reprogram yeast used for millennia in the fermentation of wine and beer, so that these fast-growing cells convert sugar into hydrocodone, a derivative of an opiate, in just three to five days.

This industrial process now takes a year between the harvesting of the legally grown poppy and the production of painkillers by pharmaceutical laboratories, note the researchers.

Hydrocodone and related chemicals like morphine and oxycodone are a family of pain relievers derived from opium, which is derived from poppy latex.

The quantities produced are still minimal. It takes 16,600 liters of yeast treated with this bioengineering technique to produce a single dose of hydrocodone, the researchers say. But, they argue, the experiment proves that it is possible to genetically manipulate yeast to obtain plant-derived drugs, points out Christina Smolke, professor of bioengineering at Stanford University, who led the research. .

The production of the anti-malarial artemisinin from genetically modified yeast was the first major bioengineering success in making a drug that until then had only been produced from mugwort.

Over the past ten years, a third of the world’s production of artemisinin has been converted and now comes from bio-technology.

But this process was relatively simpler, requiring only six genes to be inserted into yeast to make artemisinin. For hydrocodone, it is much more complex. Scientists had to use 23 genes to create the cell factory capable of producing this derivative.

Appearance, what does it look like?

The most commonly used (and misused) buy oxycodone online USA drugs are Oxycontin and Oxynorm. Oxycodone is a step 3 opioid analgesic like morphine or fentanyl.

Legality

Oxycodone is on the list of French narcotics. It must be prescribed by secure prescription and its prescription and supply are limited to 28 days.

Detection in biological fluids

Oxycodone and/or its major metabolites can be detected in blood or urine. Many commercial opiate screening tests cross-react with oxycodone and its metabolites.

The dosage

Oxycodone is 1.5 to 2 times more potent than morphine (per os). The conversion factor (in per os dose, that is to say by the oral route) is 1.5 to 2, ie 10 mg of morphine = 5 mg of oxycodone.

A single dose of more than 40mg taken or a daily dose of more than 80mg is too much for a person with no opiate tolerance.

Consumption patterns

An injectable preparation of Oxycontin that is double filtered with a cotton filter and a spinning top filter

Oxycodone can be taken orally, intranasally, intravenously, intramuscularly or subcutaneously, or rectally (plug).

The bioavailability of oral administration of oxycodone averages 60-87%, with rectal administration giving the same results; The intranasal route varies between individuals with an average of 46%.

When it is not in LP and when it is ingested, oxycodone takes between 10 and 30 minutes before starting to take effect, and lasts between 4 and 6 hours.

Oxycodone and OST

Although oxycodone does not have Marketing Authorization for this indication, it can be used by some doctors as OST (Opiaceous Substitution Treatment). So when I get home I go back to see my doctor, as well as my addict, and I finally go to the sub.

I found a comfortable dosage at 10-12mg/day, but mm if physically everything was fine, the cravings were absolutely not calm despite the 250mg of seresta that I had per day.

So I switched to metha, induced at 60mg, going to 70 a week later, to arrive at a comfort dose if we can say At 110mg/d

But from 60 to 110mg, even if I always appreciate the stability that this molecule can bring, I really experienced it badly, a very marked depressant effect, I saw it as an emotional straightjacket, no more joy, envy or sadness , I felt like a robot, Neither me nor my friends recognized me.

So I talked to my doc about it, who suggested I add an AD, which I refused, I didn’t want another addiction.

So I asked for a skenan protocol. But in Brittany loxy A almost replace morphine, because of the problems of diversion of skenan, it is very hard to have some. While L oxynormORO is very prescribed towards us.

So given the 2 treatment failures approved by my doctor, I had the agreement for a different protocol, but as he knows that I tend to divert my medications, whether sniff or injection, he preferred to prescribe me of loxy, due to its high oral bioavailability, it allows me to switch from IV to per os, without having to really change the dosages.

So I started at 100mg a day, to find a comfortable dose at 200mg, and mtn for a little over 9 months, I’ve been at 160-170mg, I’ve lowered the seresta to 150mg/day and have basically stopped the noctamide, I found myself passing A loxy. .

The risks of consumption

Common side effects of oxycodone US pharma include constipation (23%), nausea (23%), vomiting (12%), drowsiness (23%), dizziness (13%), itching (13%) , dry mouth (6%) and sweating (5%). Less common side effects (less than 5% of patients) are loss of appetite, nervousness, abdominal pain, diarrhea, urinary retention, dyspnoea and hiccups. Oxycodone can also cause bradycardia, apnea, hypotension, miosis, circulatory leak, and respiratory arrest.