Introduction: The application of alanine in medicine and health products, daily chemicals, food and food additives industries. L-alanine is the raw material for synthesizing vitamin B6, proglutamate dipeptide, etc. As a nutritional fortifier or supplement, it can be used to prepare amino acid injections. It is an important raw material for the therapeutic drug sofosbuvir and the new multiple sclerosis drug glatiramer acetate.
Alanine has a very wide range of uses in medicine and health products, daily chemicals, food and food additives and other industries.
(1) The field of medicine and health care products
L-alanine is the raw material for synthesizing vitamin B6, proglutamate dipeptide, etc. As a nutritional fortifier or supplement, it can be used to prepare amino acid injections. It is an important raw material for the therapeutic drug sofosbuvir and the new multiple sclerosis drug glatiramer acetate.
L-alanine is a natural and healthy liver-protecting formula ingredient, which can effectively reduce the degree of alcoholism. Studies have shown that L-alanine also has huge potential applications in the field of drug sustained-release agents, diabetes drugs and primary liver cancer drugs.
Beta-alanine is one of the few precursors of carnosine. Supplementation of beta-alanine helps to increase the content of carnosine in muscle tissue, thereby eliminating muscle fatigue and improving muscle activity.
Beta-alanine is also an important raw material for the synthesis of vitamin B5 (calcium pantothenate).
(2) Daily chemical field
L-alanine can be used to synthesize green and environmentally friendly mild amino acid surfactants. Compared with traditional surfactants, this kind of mild amino acid surfactants can achieve the same effect as traditional organic chemical surfactants, and at the same time, it is friendly to the environment, is good for human health, and has good decontamination, emulsifying and penetrating abilities. And excellent toning, moisturizing ability, suitable for sensitive skin and infants.
L-alanine can be used to produce novel chelating agents such as MGDA. One of the main types of traditional chelating agents is polyphosphate chelating agents, including sodium tripolyphosphate (STPP), sodium hexametaphosphate, sodium polyphosphate and sodium pyrophosphate, etc. Due to their phosphorus content, entering lakes and rivers will cause The water body is eutrophic and the algae multiply, thus destroying the entire water body ecosystem. MGDA can replace the components of phosphorus-containing chelating agents in new high-performance environmentally friendly detergents, which can be naturally degraded in water, avoiding the negative impact of traditional phosphates on the environment and avoiding harm to the human body and the environment. Because polyphosphate chelating agents are not conducive to consumers’ health and ecological environment, developed countries in Europe and the United States are gradually restricting and prohibiting their use. Washington state in the United States has banned phosphates in all detergents since the first quarter of 2008, France has begun to levy sodium tripolyphosphate (STPP) use tax as early as 2009, and in 2010, 16 states in the United States have banned the sale of phosphate content More than 0.5% of household dishwasher detergents, from 2017 EU member states limit the use of phosphates in dishwashers and detergents to no more than 0.3g per standard dose of the substance. In China, in 2012, the Ministry of Land and Resources has included the new projects of sodium tripolyphosphate and sodium hexametaphosphate production units into the “Catalogue of Prohibited Land Use Projects (2012 Edition)”. This is all conducive to the development of a new chelating agent, MGDA, which will drive a substantial increase in the demand for alanine.
(3) Food and food additives
Alanine is a natural and green food additive, which can enhance the umami taste, reconcile salty and sour taste, relieve spicy, bitter and astringent taste, etc., play a role in softening the overall taste of food, and also has the effect of triggering the deliciousness of food materials themselves. effect, and does not contain sodium ions, which is safer and healthier. Alanine is widely added to fish sauce, soy sauce, salty essence, sake and other products.
L-alanine is one of the amino acids with the highest content in protein. It has a special sweetness and aroma, and can be mixed with other aroma substances to show a more advanced aroma. Compared with other flavor enhancers, L-alanine is unique in that it participates in the cycle of amino groups and the conversion of amino acids and glycogen in the body. It has important application value and is also an element of delicious food.
DL-alanine is often used together with sodium L-glutamate and glycine as a delicious seasoning. DL-alanine also has the functions of buffering acid and alkali, chelating heavy metals and preventing the browning of other amino acids. It has been used in Japan and Korea. And other countries are commonly used as nutritional fortifiers and flavoring agents.
(4) Other fields
As an amino acid required by the body, L-alanine plays a very important role in amino acid metabolism in animals. Adding a certain amount of L-alanine to animal feed can promote animal growth, relieve stress and prevent diseases; L-alanine can be used to prepare new environmentally friendly herbicides and other pesticide products; L-alanine It can also be used as a monomer compound for the preparation of degradable biomaterials. In the above fields, L-alanine has been recognized and widely used in the European Union.