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The difference between tylosin,tyvalosin and tiamulin

by arshine

There are three antibiotics, tylosin, tyvalosin and tiamulin that are available on the market now. Due to the difference in the drug names, many pig farmers are always confused, but they can be treated individually. There are differences in the diseases of the three types of drugs, so what is the difference between these three drugs, and how to use them for the best effect? Today, I will share with my pig friends about the antibiotics of these three “Thai characters”.

1. Different classifications
Tylosin belongs to the first generation of macrolide drugs. It was extracted from the culture solution of Streptomyces flexneri by an American company in 1959. At present, the phosphoric acid of tylosin is commonly used in clinic. salt and tartrate.
Tylosin is a third-generation macrolide drug, which was prepared by Japanese scientists in the 1980s through acetylation, isovalerylation and alcoholysis of tylosin, also known as synthetic acetyl isopentyl. Acyl tylosin. The most commonly used in clinical practice is tartrate.
Tiamulin belongs to dipterene antibiotics, which was developed by Australian scientists in 1951. It is obtained by fermenting pleuromutilin from Basidiomycetes Pleurotus and then chemical synthesis. The current clinical use is fumarate.
2. For different diseases,
Tylosin is mainly aimed at Gram-positive bacteria, and is also effective against some Gram-negative bacteria. It is also one of the drugs with the strongest effect on Mycoplasma among macrolides. But tylosin is ineffective against PRRS.
The antibacterial spectrum of tylosin is similar to that of tylosin, but tylosin can accumulate in alveolar macrophages, the main replication site of PRRS virus, thereby changing the internal pH of alveolar macrophages, resulting in alveolar macrophages. The interior is acidic, and the PRRS virus likes an alkaline environment, which can inhibit the replication of the PRRS virus, thereby achieving the effect of preventing and treating PRRS.
Tiamulin, the antibacterial spectrum of tiamulin is also similar to tylosin, mainly has a strong inhibitory effect on gram-positive bacteria, but has a weaker effect on gram-negative bacteria, especially intestinal bacteria. The effect on mycoplasma is better than that of macrolides, and tiamulin is also ineffective against PRRS.
3. How to use the best effect?
1) Tylosin
According to the antibacterial spectrum of tylosin, it has better effect on Gram-positive bacteria. Currently, it is mainly used in the clinical treatment of various streptococcal infections and Staphylococcus aureus infections. It can also be used to treat Mycoplasma suis pneumonia and Mycoplasma synovialis. resulting in swelling of the joints. In addition, it also has a certain therapeutic effect on swine dysentery caused by Treponema.
Incompatibility of tylosin: Tylosin will produce antagonistic effects with other macrolides, lincosamides, tylosin, and beta-lactams, and it is not easy to use in combination. Clinically, it can be used together with doxycycline and sulfonamides to expand the antibacterial spectrum and enhance the efficacy.

Tyvalosinwas developed to solve the two problems of bacteria and mycoplasma resistance to tylosin and low blood concentration, so in theory, the diseases that tylosin can treat, Tyvalosin can be treated; however, it is currently mainly used for the prevention and control of porcine PRRS.
For PRRS, it is recommended to add 20% tyvalosin + Banlangen granules + Fuzheng Jiedu powder for 10-14 days every month.
3) Tiamulin
has a weak effect on Gram-negative bacteria, especially intestinal bacteria, so tiamulin is mainly used to treat various respiratory diseases, such as mycoplasma, suis streptococcosis, Staphylococcus aureus, porcine infectious pleuropneumonia, porcine treponemal dysentery, porcine proliferative ileitis, etc. Among them, the effect on Mycoplasma suis infection and proliferative ileitis is better than that of macrolides.


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