What Is Diosmin?


Diosmin (7-o-Rutinoside) is a flavonoid glycoside of diosmetin made from the skin of citrus fruits and used as an over-the-counter intravenous dietary supplement to help treat hemorrhoids or chronic venous conditions, mainly in the legs.


Diosmine is a dietary supplement used to help treat hemorrhoids and venous disorders, namely chronic venous insufficiency, including spiders and varicose veins, leg swelling (edema), stasis dermatitis, and venous ulcers. The mechanism of action of diosimine and other hemostatic agents is unclear and clinical evidence is limited. Diosmine is not recommended for the treatment of rectal mucosa, skin irritation or wounds, nor should it be used to treat dermatitis, eczema or urticaria. Diosmine is not recommended for use in children or women during pregnancy. Moderate quality evidence suggested that diosmine or other intravenous agents improved leg and ankle swelling and calf pain, while low quality evidence suggested treatment of hemorrhoids.


Included in a small class of drugs called “phlebotonics”, diosmine has a heterogeneous composition, partly made up of citrus peel extracts (flavonoids such as hesperidin) and synthetic compounds, and is used to treat chronic venous insufficiency or hemorrhoids.


Chronic venous disease working group in 2017, the United States, it is recommended to use micronization purified flavonoid constituents (diosmiplex) as a treatment for chronic venous disease symptoms and venous ulcer of health food, with “no serious adverse events of beneficial results”, alone or combined with pressure therapy, agree with the guidance of the international society for vascular surgery in Europe previously. The German Academy of Dermatology notes that diosmine can be used with other drugs to treat symptoms of chronic venous disease.


The American Society of Colon and Rectal Surgeons mentions phlebotonics as a possible treatment for symptoms of hemorrhoid grades I to II, as there is only moderate-quality evidence of effectiveness with “expectations of minimal harm”, while having no evidence of long-term benefit. French, Indian, Portuguese, and Italian professional societies of coloproctology issued similar recommendations regarding phlebotonics for hemorrhoids.


In some 10% of users, diosmin causes mild gastrointestinal disorders or skin irritations (hives, itching), stomach pain, nausea, heart arrhythmias, or anemia. Preliminary research indicates no evidence of toxicity. The US Food and Drug Administration (FDA) concluded in 2001 that there was inadequate evidence on which to base an expectation of safety. As of 2013, the FDA did not revise this position.


Diosmin is distributed in the U.S. as a dietary supplement called Daflon. Diosmin is not approved as a prescription drug in the United States or Europe. Phlebotonics are not approved in Germany, and are restricted in Spain only for the treatment of chronic venous diseases.


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