What is Parkinson’s disease?

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Parkinson's

What is Parkinson’s disease?

Parkinson’s disease is a chronic condition that affects the central nervous system, especially the motor system of the body. As the motor system is affected, the first symptoms of this condition are always related to the physical movements of the body such as difficulty in walking and running, slower movements, rigid muscles, and tremors.

As the condition progresses, symptoms that are not related to movement begin to appear such as mental health conditions such as depression, and anxiety.

The brain cells substantia nigra that are responsible for producing dopamine in the body are affected and are damaged due to this condition which causes low production of dopamine in the body.

This condition is neither reparable, nor are there any solid markers that can help in finding the reasons for this condition, yet there are different medicines that can improve the side effects of Parkinson’s illness.

 

The Connection between Parkinson’s disease and Dopamine

As Parkinson’s disease affects the central nervous system, you will see gradual damage in all the neurotransmitters that play a vital role in various functions of our body, but the link between dopamine and Parkinson’s disease is the strongest.

There are various reasons for it, but let’s talk about the role of dopamine in the smooth functioning of our physical movements.

The basal ganglia are the part of the brain that is in control of the physical movement of the body and Dopamine produced in this particular region affects the very movements that it controls.

Talking about the part of dopamine in Parkinson’s illness, when there isn’t sufficient creation of Dopamine in the Basal ganglia, there can be issues in completing the actual developments.

It has been found that people who suffer from Parkinson’s disease have a low amount of Dopamine production and as their central nervous system degenerates with it, it gets lower and lower with time. And thus, the symptoms of Parkinson’s disease become worse.

Apart from movement, dopamine is the chemical messenger that allows us to feel pleasure and motivates us to achieve something desirable. It is the neurotransmitter that ignites a desire in our body for a reward and also the pleasure associated with it.

We know that the first signs of Parkinson’s disease can often be noticed in weaker physical movements and slower reflexes, and we have already linked the involvement of lack of the chemical messenger Dopamine with those symptoms.

But the other symptoms that can be observed in people suffering from Parkinson’s disease are mood disorders such as anxiety and depression.

The arrival of the synapse dopamine is imperative for us to propel us to feel the longing for a prize. This chemical messenger is also responsible for our moods and thus we can see that a dip in dopamine production can lead to mood disorders which are common symptoms of Parkinson’s disease.

Apart from the difficulty in making physical movements, and mood disorders such as depression and anxiety, Parkinson’s disease also shows degeneration in the cognition function and conditions such as dementia.

Thus, we can say that the imbalance of dopamine, especially less production of this pleasure-giving neurotransmitter can cause memory problems, weaken cognitive functions, and cause mood disorders such as anxiety and depression along with the deterioration of physical movements.

All these are symptoms of Parkinson’s disease and thus many studies strongly suggest that the role of dopamine is vital in the treatment of the incurable condition.

 

The Available Treatments 

Parkinson’s disease is a fatal condition, though it takes a long time to show complete degeneration of the entire nervous system.

There is absolutely no cure for this condition, and one reason behind this setback of medical science is the fact that the cause of the condition is not evident or definite.

The most that people have found after various tests and studies is the possibility that this condition may be caused due to low dopamine levels produced and its gradual decrease with time.

Yet, in view of the assessment of the different instances of Parkinson’s illness in this condition can be followed back to results of certain clinical medications like phenothiazine and metoclopramide.

 

How Does the Combination of Levodopa+ Carbidopa + Entacapone Treatment Help for Managing Parkinson’s illness?

To the extent restorative medicines are thought of, individuals experiencing Parkinson’s sickness are endorsed which are taken as a blend of Levodopa, Carbidopa, and Entacapone.

And these drugs bring us back to the potential of Dopamine Supplements as a reliable treatment of Parkinson’s disease.

We need Dopamine Boosters such as Levodopa, being a precursor of Dopamine can reach the brain and can thus be converted into Dopamine in the Basal Ganglia of the brain.

The drugs Carbidopa and Entacapone are both given to ensure that adequate amounts of Levodopa drug can pass to the brain for the adequate conversion of Dopamine in the body. Both these drugs essentially prevent the effects of Levodopa to wear off before the time of the next dosage of the condition.

There are various brands of these drugs available in the market such as Entacom and Syncapone which are prescribed in combination for the treatment of Parkinson’s disease.

Using these three drugs together has proved to show modest results, and allows the person suffering from Parkinson’s disease to live a more satisfactory life.

Aside from the utilization of oral prescriptions, physiotherapy is additionally recommended for the treatment of Parkinson’s sickness, however, more often than not, it is for improving the indications identified with the actual developments of the body. However, the non-intrusive treatment appears to show more negative effects as the degeneration of neurons in the substantia nigra starts to increase.

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